Dopamine Receptor
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.
Dopamine Receptor Isoform Specific Products
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Dopamine Receptor Inhibitors
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Dopamine Receptor Agonists
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Dopamine Receptor Antagonists
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Dopamine Receptor Activators
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Dopamine Receptor Modulators
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Dopamine Receptor Chemical
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Dopamine Receptor MDM2 Inhibitor
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Dopamine Receptor Controls
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Dopamine Receptor Ligands
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Dopamine Receptor Related Products (1078)
Related Products (1078)
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Antibodies (7)
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Related Compound Screening Libraries (1)
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Dopamine Receptor Isoform Comparison
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Savoxepin mesylate
0 ImagesCat. No.: HY-119385CAS No.: 79262-47-8Savoxepin mesylate is a D2 dopamine receptor (D2 Dopamine Receptor) antagonist with antipsychotic activity. Savoxepin mesylate selectively blocks dopamine D2 receptors in the hippocampus while having no significant effect on D2 receptors in the striatum. This selective blockade helps reduce the risk of extrapyramidal side effects (EPS).
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(S)-Remoxipride hydrochloride hydrate
0 ImagesCat. No.: HY-101313BCAS No.: 117591-79-4Synonyms: (-)-Remoxipride hydrochloride hydrate(S)-Remoxipride ((-)-Remoxipride) hydrochloride hydrate ((S)-Remoxipride hydrochloride hydrate) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride hydrochloride hydrate can be used for the research of psychotic disorder.
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Olanzapine ketolactam
0 ImagesCat. No.: HY-Z4466CAS No.: 1017241-34-7Olanzapine ketolactam (compound 1) is the impurity of Olanzapine (HY-14541). Olanzapine is a selective, orally active monoaminergic antagonist.
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UNC9994 hydrochloride (Standard)
0 ImagesCat. No.: HY-111385RCAS No.: 2108826-33-9UNC9994 hydrochloride (Standard) is the analytical standard of UNC9994 (hydrochloride) (HY-111385). This product is intended for research and analytical applications. UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity.
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SNAP8719 free base
0 ImagesCat. No.: HY-123514CAS No.: 255893-38-0SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response.
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Milenperone
0 ImagesCat. No.: HY-121898CAS No.: 59831-64-0Milenperone (R 34009) is a dopamine atagonist. Milenperone can be used in the study for neurological disease.
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Talipexole dihydrochloride (Standard)
0 ImagesSynonyms: B-HT 920 dihydrochloride (Standard)Talipexole (dihydrochloride) (Standard) is the analytical standard of Talipexole (dihydrochloride). This product is intended for research and analytical applications. Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
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Propionylpromazine (Standard)
0 ImagesCat. No.: HY-111480RCAS No.: 3568-24-9Propionylpromazine (Standard) is the analytical standard of Propionylpromazine (HY-111480). This product is intended for research and analytical applications. Propionylpromazine is a dopamine receptor DRD2 antagonist. Propionylpromazine also is an effective tranquillizer. Propionylpromazine can be used in veterinary studies.
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4-EEC hydrochloride
0 ImagesCat. No.: HY-158552CAS No.: 2446466-62-04-EEC hydrochloride is a synthetic stimulant substance. 4-EEC hydrochloride is a releasing agent for norepinephrine-dopamine.
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Pipamperone (Standard)
0 ImagesCat. No.: HY-100703RCAS No.: 1893-33-0Synonyms: Floropipamide (Standard); McN-JR 3345 (Standard); R 3345 (Standard)Pipamperone (Standard) is the analytical standard of Pipamperone (HY-100703). This product is intended for research and analytical applications. Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease.
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Thiethylperazine (Standard)
0 ImagesThiethylperazine (Standard) is the analytical standard of Thiethylperazine. This product is intended for research and analytical applications. Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.
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Desethoxy Quetiapine dihydrochloride
0 ImagesCat. No.: HY-W151617ACAS No.: 329218-14-6Desethoxy Quetiapine dihydrochloride (Compound 28) is an antagonist for dopamine D2 receptor with an IC50 of 1330 nM. Desethoxy Quetiapine dihydrochloride antagonises Apomorphine (HY-12723)-induced climbing and swimming disruption in mouse models.
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Paliperidone palmitate (Standard)
0 ImagesSynonyms: 9-Hydroxyrisperidone palmitate (Standard)Paliperidone palmitate (Standard) is the analytical standard of Paliperidone palmitate. This product is intended for research and analytical applications. Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia.
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SKF 83509
0 ImagesCat. No.: HY-111160CAS No.: 90955-43-4SKF 83509, a desmethyl analogue of SCH 23390 (HY-19545A), is a selective dopamine D1 antagonist with a Ki of 70.2 nM. SKF 83509 has no activity at dopamine D2 receptors.
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Asenapine-d3,13C
0 ImagesCat. No.: HY-10121S4CAS No.: 1217729-73-1Synonyms: Org 5222-d3,13CAsenapine-d3,13C (Org 5222-d3,13C) is deuterium and 13C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
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Domperidone-13C6
0 ImagesCat. No.: HY-B0411S2Synonyms: R33812-13C6Domperidone-13C6 (R33812-13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.
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Sonepiprazole hydrochloride
0 ImagesCat. No.: HY-14328ACAS No.: 170857-36-0Synonyms: PNU-101387G hydrochloride; U-101387G hydrochlorideSonepiprazole (PNU-101387G) hydrochloride is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.
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Cariprazine impurity 1
0 ImagesCat. No.: HY-47412CAS No.: 791778-53-5Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway.
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BL-1020 mesylate
0 ImagesCat. No.: HY-111136CAS No.: 916898-61-8BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate.
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FR 64822
0 ImagesCat. No.: HY-105294CAS No.: 102671-35-2FR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks.
